Md Imdadul H Khan
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Ph.D in Pharmaceutical Sciences (University of Mississippi, United States) Masters of Pharmacy (University of Dhaka, Bangladesh) Bachelor of Pharmacy (University of Dhaka, Bangladesh) Higher Secondary Certificate (HSC) (Faujderhat Cadet College) Secondary School Certificate (SSC) (Faujderhat Cadet College) |
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| imdad@nstu.edu.bd | |
| 1-662-6073934 | |
| Blood Group: | |
| Joining Date : 2015-10-05 | |
| Research Interests:
a. Natural product chemistry: i. Isolation and characterization of secondary metabolites from endophytic fungi and plants. ii. Biological screening of isolated compounds and further optimization of these compounds following semisynthetic approach to treat pain, cocaine withdrawal behavior, and microbial diseases. b. Rational drug design for Cancer and infectious diseases such as HIV, malaria, and MRSA : i. Glutamine-based drug discovery to inhibit glutaminolysis pathway which is the major source of energy for cancers. ii. Discovery of allopregnanole-based molecule/s as neuroprotective agent against HIV tat-mediated neurotoxicity and HIV viremia. iii. Discovery of naphthoquinone-based molecules as anti malaria and anti-MRSA agents. c. Reaction Methodology: Development of mild and efficient methodology of bioorthogonal chemistry. |
About Md Imdadul H Khan
Md Imdadul H Khan has been completed his Bachelors in the department of pharmacy of the University of Dhanka, Bangladesh. In the same university, he has been completed his Masters in the department of Pharmaceutcal Chemistry, Bangladesh under the supervision of Dr. Abdul Mazid. He worked on isolation of endophytic fungi from the plant Rauwolfia Serpentina; large scale cultivation, extraction of isolated endophytic fungi Cladosporium sp, and purification and characterization of two cytotoxic and antimicrobial fusarubin molecules from the crude extract of Cladosporim sp.
Currently he is pursuing his Ph.D in the division of Medicinal Chemistry of the University of Missippi in United States under the supervision of Dr. Hoang V Le. He is working on design and synthesis of potential therapeutic for pain, cancer and infectious diseases such as HIV, malaria, and MRSA. He is also working on the developement of reaction methodology to expand the scope of functionalization of bioorthogonal chemistry.
Using rational drug design approach along with computational tools this group discover lead molecule as well as optimize the existing leads. Their synthetic strategy invovles both semi-synthesis of natural product molecules and synthesis from commercially available molecules. They design efficient and economic multistep synthetic route to synthesize those designed molecules. During the process they develop new methodology or optimize the existing one for certain reactions. Collaboration with different biology labs help to guide them toward the discovery of novel therapeutics for aforementioned diseases.
Publications
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Research Articles (Selected) 10. Khan, M.I.H.; Yang, J.; Kim, S.J.; Le, H.V.; A New Reaction of Togni II Reagent: α-Esterification of Protected Amides. 2022 (In preparation)
9. Khan, M.I.H.; Mahdi, F.; Penfornis, P.; Hossain, M.I.; Akins, N.S.; Kim, S.J.; Tran, T.D.; Claudio, P.P.; Paris, J.J.; Le, H.V.; Development of tert-Butyl Ester and Ethyl Ester Prodrugs of L-γ-Methyleneglutamic Acid Amides for Cancer. Bioorganic & Medicinal Chemistry. 2022 (In preparation)
8. Khan, I.H.K.; Bee, M,; Kim, S.J.; Le, H.V. Efficient synthesis of atovaquone. 2022 (In preparation)
7. Khan. M.I.H.; Mahdi. F.; Elhanafy, E.; Salahuddin, M.S.; Akins, N.S.; Kim, S.J., Li, J.; Paris, J.J.; Le, H.V.; Discovery of 5α-pregnan-2β,3α-diol-20-one as a neuroHIV protective agent. 2022 (In preparation)
6. Kim, S.J.; Li, Y.; Mahoney, A.R.; Khan, M.I.H.; Tripathi, S.K.; Khan, S.I.; Wuest, W.M.; Riscoe, M.; Le, H.V.; Novel 2-Hydroxy-1,4-naphthoquinones as Drug-resistant Antimalarials and Antibacterials. ACS infectious diseases. 2022 (In preparation)
5. Akins, N.S.; Mohammad, S.F.; Pandey, P.; Kim, S.J.; Mahdi, F.; Khan, M.I.H.; Moss, E.; C Worth, C.; Keanne, M.; Chittiboyina, A.; Doerksen, R.; Paris, J.J.; Le, H.V.; Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-based Antagonists and Kappa Opioid Receptor. ACS Chem Neurosci, 2022 (submitted)
4. Hossain, M.I.; Khan, M.I.H.; Kim, S.J.; Le, H.V.; Synthesis of 3, 4, 5-Trisubstituted Isoxazoles in Water via a [3+ 2]-Cycloaddition of Nitrile Oxides and 1, 3-Diketones, β-Ketoesters, or β-Ketoamides: Base-mediated and Keto-enol-controlled Mechanism. Beilstein J. Org. Chem. 2022, 18, 446–458
Before Ph.D
3. Ahamed S.K.; Khan M.I.H.; Billah M.M.; Hossain S.M.; “Methanol extract of Solanum violaceum root possesses antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity,” Marmara Pharmaceutical Journal, 2018, 22(1), 96-102.
2. Alam, N.A.; Rahman, M.A.; Khan, M.I.H.; Singha, A.C.; “New strategy for Microbial Tests Validation in Pharmaceutical industry,” Journal of Noakhali Science and Technology University (JNSTU), 2017, 1(1), 47-50.
1. Khan M.I.H.; Sohrab, M.H.; Rony S.R.; Tareq F.S.; Hasan C.M.; Mazid M.A.; Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp., Toxicology Reports, 2016, 3, 861-865. Review Article 1. Khan, M.I.H.; Akins, N.S.; Sawyer, B.; Le, H.V.; The Complexity of Kappa Opioid Receptor and Ligands: Implications in Pain, Anxiety, Depression, and Drug Abuse. RSC Medicinal Chemistry. 2022 (invited) Book Chapter 1. Sawyer, B.; Khan, M.I.H.; Le, H.V.; Antimalarial drugs; Medicinal Chemistry of Chemotherapeutic Agents, Elsevier, 2022, ISBN: 9780323905756 Conferences (Selected) Khan, M.I.H. et al. Discovery of 5α-pregnan-2β,3α-diol-20-one as a neuroHIV protective agent. 47th Annual MALTO Medicinal Chemistry and Pharmacognosy Meeting, 2022, Olemiss, MS, USA.
Khan, M.I.H. et al. Discovery of 5α-pregnan-2β,3α-diol-20-one as a neuroHIV protective agent. ACS Fall, 2021, Atlanta, Georgia, USA
Kim, S.J.; Khan, M.I.H., Sawyer, B.; et al. New Hydroxy-1,4-naphthoquinone and phenoxy-phenyl-naphthoquinone compounds as drug-resistant antimalarials. ACS Fall, 2021, Atlanta, Georgia, USA
Hossain, M.I.; Mahdi, F.; Khan, M.I.H. et al; Development of L-γ-Methyleneglutamine based compounds for cancer. UM School of Pharmacy Annual Poster Session, 2021, Oxford, Mississippi, USA
Khan, M.I.H.; et al. Discovery of 5α-pregnan-2β,3α-diol-20-one as a Neuroprotective Agent Against the HIV-1 Regulatory Protein Tat. Joint SWRM/SERMACS Regional Meeting, 2020, Hilton New Orleans Riverside, Louisiana, USA. (Abstract was accepted for oral presentation. However, meeting was later canceled due to COVID-19)
As a part of graduate student recruitement team, participated in Southeastern Undergraduate Research Conference (SURC) 2018, The University of Tennessee Martin, Tennessee, USA.
Al-Mamun A, MT Hossain, MHA Rashid, M Asadujjaman, MA Sufian, FBA Salam, MIH Khan, SH Chadni, A Sukul. Phytochemical Screening and Antidiarrhoeal Activity of Anonna squamosa L., Calotropis procera R.Br. and Piper betel L. 1st DRDC International Conference, 2015, Dhaka, Bangladesh.
M Rahman, A Khatun, HA Rashid, MA Sufian, FBA Salam, MIH Khan, SH Chadni, A Sukul, M Uddin. Methods for bio-evaluation of traditional medicines, Ayurved and Naturopathy Association of Bangladesh, 2014, Dhaka, Bangladesh. |
Experiences and Activities
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RESEARCH EXPERIENCES Research Assistant | 2018-Present Department of Biomolecular Sciences, University of Mississippi, Oxford, MS-38655.
Internship | 2011 Novartis (Bangladesh), Dhaka, Bangldesh.
Research Assistant | 2012-2013 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
TEACHING EXPERIENCES Teaching Assistant | 2019-2020 Department of Biomolecular Sciences, University of Mississippi, Oxford, MS-38655.
Lecturer | 2015-Present (On leave to pursue Ph.D.) Department of Pharmacy, Noakhali Science and Technology University, Noakhali-4316, Bangladesh.
Lecturer | 2014-2015 Department of Pharmacy, Northern University Bangladesh, Dhaka-1000, Bangladesh.
MEMBERSHIPS/ACTIVITIES American Chemical Society 2021-present ACS Medicinal Chemistry Division 2020-present The Rho Chi Society (The Academic Honor Society in Pharmacy) 2020-present Graduate Student Council Senator, University of Mississippi 2020 Association of Bangladeshi Students and Scholars (ABSS)-Ole Miss (University of Mississippi) 2019-2020 Bangladesh Pharmaceutical Society 2014-present Administrative coordinator of 1st Bangladesh Biology Olympiad central committee 2015-2017 Editorial member of BigganChetona (Journal of Bigganchetona porishod) 2010- Editorial member of Jiggasa (science magazine for teenager) 2010- Member of Bigganchetona Porishod 2008-present Convener of Bigganchetona porishod, Dhaka University (science organization) 2008-2011 |