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Assistant Professor

Otun Saha

Dr. Otun Saha is a Ph.D. student at Washington State University, specializing in food microbiology with a focus on probiotics, antimicrobial resistance, and the dairy microbiome. He has been working as an Assistant Professor in the Department of Microbiology at Noakhali Science and Technology University, where he is currently on study leave. He has extensive research experience in microbial phenotypic analysis, molecular biology, zoonotic pathogens, cell culture, GC-MS, computational biology, and genomics. Before joining WSU, he worked at the Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh, where he contributed to research on influenza, Salmonella, and antimicrobial resistance. Dr. Saha has published more than 50 peer-reviewed papers, which have been cited over 1,050 times globally. His research aims to develop probiotic-based strategies to improve gut health, enhance food safety, and disrupt antimicrobial resistance transmission within the One Health framework. Passionate about integrating science with community impact, he also leads initiatives to raise awareness about probiotics and antimicrobial resistance among the Bangladeshi community in Pullman.

Microbiology

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Biography

Dr. Otun Saha is a Ph.D. student at Washington State University, specializing in food microbiology with research interests in probiotics, antimicrobial resistance, and the dairy microbiome. He has been serving as an Assistant Professor in the Department of Microbiology at Noakhali Science and Technology University, Bangladesh, where he is currently on study leave to pursue his doctoral studies. Dr. Saha has extensive experience in microbial phenotypic analysis, molecular biology, zoonotic pathogens, cell culture, GC-MS, computational biology, and genomics. Before joining WSU, he worked at the Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh, where he contributed to research on influenza, Salmonella, and antimicrobial resistance. He has published over 50 peer-reviewed papers with more than 1,050 citations globally. His research focuses on developing probiotic-based strategies to enhance food safety, improve gut health, and mitigate antimicrobial resistance within the One Health framework.

Research Interests

Food Microbiology Veterinary Microbiology

PhD

Microbiology

University of Dhaka

2018 - 2022

MS

Microbiology

Noakhali Science and Technology University

2016 - 2017

Hons

Microbiology

Noakhali Science and Technology University

2010 - 2016

Last updated on 2025-10-05 23:48:10

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2019-06-05

A bacterial whole genome and metagenomics training program

Description: Seven-day hands-on training on bacterial whole-genome and metagenomic analysis, followed by RT-PCR.

Organization: Thermo Fisher Scientific Laboratories Gurgaon, India

2018-12-01

A bacterial whole genome, RT-PCR, and Sanger sequencing training program

Description: Seven days of practical training on bacterial whole-genome and metagenomic analysis, including RT-PCR.

Organization: Jessore University of Science and Technology, Bangladesh

2015-05-20

A biotechnological training program

Description: Cell culture, PCR, RT-PCR, Plant genomic study, Tissue culture

Organization: National Institute of Biotechnology, Savar, Bangladesh

Last Updated: 2025-10-06 00:15:26

2018-06-20

A workshop on “Bioinformatics Basic Analysis

Description: Computational Biology

Organization: NSU Bioinformatics Fronties

Last Updated: 2025-10-06 00:17:06

Awards and Achievements

Cascadia IFT student achievement awards

Washington State University

Alexander A. Smick Scholarship for Rural Community Service and Development

Washington State University

Journal

Characterization and comparative modeling of iron superoxide dismutase B1 (FeSODB1) of Leishmania donovani using an in silico approach

Authors: Adhikari, Utpal Kumar and Saha, Otun and Ahmmed, Mostaq and Sultana, Afroza and Rahman, Ferozur and Islam, Kamrul and Hasan, Mehedi

Journal: International Journal of Computational Bioinformatics and In Silico Modeling

Journal

Molecular Evolutionary Analysis of a-Defensin Peptides in Vertebrates

Authors: Rahman, Arafat and Islam, M Sahidul and Saha, Otun and Saha, Titon Chandra

Journal: Rajshahi University Journal of Science and Engineering

Journal

Comparison Between Reduced Susceptibility to Disinfectants and Multidrug Resistance Among Hospital Isolates of Pseudomonas aeruginosa and Staphylococcus aureus in Bangladesh

Authors: Islam, Tarequl and Otun Saha, Sharmin Sultana and Hridoy, Md and Hasan, Mahmudul and Marzan, Sadiatul and Rahman, Mohammad Musfiqur

Journal: Bagcilar Medical Bulletin

Journal

Occurrence of Pathogenic and Multidrug Resistant Salmonella spp. in Poultry Slaughter-House in Bangladesh

Authors: Samina Momtaz , Otun Saha , Masuma Khatun Usha , Munawar Sultana, M. Anwar Hossain

Journal: Bioresearch Communications

Journal

In-vivo evaluation of Anti-onciceptive, Anti-inflammatory, Antipyretic, Hypoxia and Gastro-intestinal potentials of SwasKas Chintamani Ras

Authors: Tarequl Islam, Md. Saddam Hussain, Ashraful Mahmud Tuhin, K. M. Rahat Maruf Jitu, Abida Sultana, Otun Saha, Dos Mohammad, Md. Shahadat Hossain, Mohammad Nurul Amin

Journal: Discovery Phytomedicine

Journal

Isolation and identification of pesticides degrading bacteria from farmland soil

Authors: Rahman, Md Atikur and Arefin, ASM Shamsul and Saha, Otun and Rahaman, Md Mizanur

Journal: Bangladesh Journal of Microbiology

Journal

In vitro comparative analysis of antibacterial activity of different fractions of Corchorus capsularis and Corchorus olitorius leaves extracts

Authors: Abir, Riad

Journal: Bangladesh Journal of Microbiology

Journal

Resistome diversity in bovine clinical mastitis microbiome, a signature concurrence

Authors: Hoque, M Nazmul and Istiaq, Arif and Clement, Rebecca A and Gibson, Keylie M and Saha, Otun and Islam, Ovinu Kibria and Abir, Ruhshan Ahmed and Sultana, Munawar and Siddiki, AMAM Zonaed and Crandall, Keith A and others

Journal: bioRxiv

Journal

Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approach

Authors: Rahman, M Shaminur and Hoque, M Nazmul and Islam, M Rafiul and Akter, Salma and Alam, ASM Rubayet Ul and Siddique, Mohammad Anwar and Saha, Otun and Rahaman, Md Mizanur and Sultana, Munawar and Crandall, Keith A and others

Journal: PeerJ

Journal

Insights into the resistome of bovine clinical mastitis microbiome, a key factor in disease complication

Journal: Frontiers in Microbiology

Journal

Overlapping of locust swarms with COVID-19 pandemic: a cascading disaster for Africa

Authors: Rahaman, Mizanur and Saha, Otun and Rakhi, Nadira Naznin and Chowdhury, Miraj Kobad and Sammonds, Peter and Kamal, ASM Maksud

Journal: Pathogens and global health

Journal

Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60

Authors: Saha, Otun and Rakhi, Nadira Naznin and Hoque, M Nazmul and Sultana, Munawar and Hossain, M Anwar

Journal: Brazilian Journal of Microbiology

Journal

Challenges to be considered to evaluate the COVID-19 preparedness and outcome in Bangladesh

Authors: Islam, Md Mirajul and Rakhi, Nadira Naznin and Islam, Ovinu Kibria and Saha, Otun and Rahaman, Md Mizanur

Journal: International Journal of Healthcare Management

Journal

Recommendation of fecal specimen for routine molecular detection of SARS-CoV-2 and for COVID-19 discharge criteria

Authors: Ahamed Mim, Moonmoon and Naznin Rakhi, Nadira and Saha, Otun and Rahaman, Md Mizanur

Journal: Pathogens and global health

Journal

Multidrug-Resistant Avian Pathogenic Escherichia coli Strains and Association of Their Virulence Genes in Bangladesh

Authors: Otun Saha, M. Nazmul Hoque, Ovinu Kibria Islam, Md. Mizanur Rahaman, Munawar Sultana, and M. Anwar Hossain

Journal: microorganisms

Journal

Microwave assisted synthesis of zinc oxide (ZnO) nanoparticles in a noble approach: utilization for antibacterial and photocatalytic activity

Authors: Ahammed, Kazi Rakib and Ashaduzzaman, Md and Paul, Shujit Chandra and Nath, Mithun Rani and Bhowmik, Snahasish and Saha, Otun and Rahaman, Md Mizanur and Bhowmik, Shukanta and Aka, Tutun Das

Journal: SN Applied Sciences

Journal

Green synthesis of iron oxide nanoparticle using Carica papaya leaf extract: application for photocatalytic degradation of remazol yellow RR dye and antibacterial activity

Authors: Bhuiyan, Md Shakhawat Hossen and Miah, Muhammed Yusuf and Paul, Shujit Chandra and Aka, Tutun Das and Saha, Otun and Rahaman, Md Mizanur and Sharif, Md Jahidul Islam and Habiba, Ommay and Ashaduzzaman, Md

Journal: Heliyon

Journal

Reactivation of severe acute respiratory coronavirus-2 (SARS-CoV-2): hoax or hurdle?

Authors: Saha, Otun and Rakhi, Nadira Naznin and Towhid, Syeda Tasneem and Rahaman, Md Mizanur

Journal: International Journal of Healthcare Management

Journal

Correction to: Microwave assisted synthesis of zinc oxide (ZnO) nanoparticles in a noble approach: utilization for antibacterial and photocatalytic activity

Journal: SN Applied Sciences

Journal

Disguising agents for transmitting Novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): Mobile phone \& Paper currency

Authors: Saha, Otun and Rakhi, Nadira Naznin and Islam, Ovinu Kibria and Rahaman, Md Mizanur

Journal: Authorea Preprints

Journal

Temporal landscape of mutation accumulation in SARS-CoV-2 genomes from Bangladesh: possible implications from the ongoing outbreak in Bangladesh

Authors: Saha, Otun and Shatadru, Rokaiya Nurani and Rakhi, Nadira Naznin and Islam, Israt and Hossain, Md Shahadat and Rahaman, Md Mizanur

Journal: BioRxiv

Journal

Genome-wide diversity and differentiation of two novel multidrug-resistant populations of Pasteurella multocida type B: 2 from fowl cholera

Authors: Saha, Otun and Islam, M Rafiul and Rahman, M Shaminur and Hoque, M Nazmul and Hossain, M Anwar and Sultana, Munawar

Journal: bioRxiv

Journal

Evaluation of commercial disinfectants against Staphylococcus lentus and Micrococcus spp. of poultry origin

Authors: Saha, Otun and Rakhi, Nadira Naznin and Istiaq, Arif and Islam, Israt and Sultana, Munawar and Hossain, M Anwar and Rahaman, Md Mizanur

Journal: Veterinary medicine international

Journal

Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh

Authors: Saha, Otun and Hossain, Md Shahadat and Rahaman, Md Mizanur

Journal: Gene reports

Journal

Drug repurposing for prevention and treatment of COVID-19: a clinical landscape

Authors: Hossain, Md Shahadat and Hami, Ithmam and Sawrav, Md Sad Salabi and Rabbi, Md Fazley and Saha, Otun and Bahadur, Newaz Mohammed and Rahaman, Md Mizanur

Journal: Discoveries

Journal

SARS-CoV-2 and COVID-19: a threat to Global Health

Authors: Saha, Otun and Rakhi, Nadira Naznin and Sultana, Afroza and Rahman, Md Mahbubur and Rahaman, Md Mizanur and others

Journal: Discoveries Reports

Journal

COVID-19 and the cardiovascular system: how the first post-modern pandemic ‘weakened’our hearts

Authors: Towhid, Syeda Tasneem and Rakhi, Nadira Naznin and Arefin, AS and Saha, Otun and Mamun, Sumaiya and Moniruzzaman, Mohammad and Rahaman, Md Mizanur

Journal: Discoveries Reports

Journal

Assessment of basic reproduction number (R0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh

Authors: Islam, Ariful and Sayeed, Md Abu and Rahman, Md Kaisar and Zamil, Shafayat and Abedin, Josefina and Saha, Otun and Hassan, Mohammad Mahmudul

Journal: Infection, Genetics and Evolution

Journal

Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.

Authors: Hossain, Md Shahadat and Pathan, AQM Sala Uddin and Islam, Md Nur and Tonmoy, Mahafujul Islam Quadery and Rakib, Mahmudul Islam and Munim, Md Adnan and Saha, Otun and Fariha, Atqiya and Al Reza, Hasan and Roy, Maitreyee and others

Journal: bioRxiv

Journal

Parallel Outbreaks of Deadly Pathogens (SARS-CoV-2, H5N8, EVD, Black fungi) around the World in 2021: Priorities for Achieving Control with Socio-Economic and Public Health Impact

Authors: Khan, Afroza and Ema, Nayeema Talukde and Rakhi, Nadira Naznin and Saha, Otun and Rahaman, Md Mizanur

Journal

Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: Possible implications from the ongoing outbreak in Bangladesh

Authors: Saha, Otun and Islam, Israt and Shatadru, Rokaiya Nurani and Rakhi, Nadira Naznin and Hossain, Md Shahadat and Rahaman, Md Mizanur

Journal: Virus genes

Journal

Multilocus sequence typing of multidrug-resistant Salmonella strains circulating in poultry farms of Bangladesh

Authors: Sultana, Khandokar Fahmida and Saha, Otun and Hoque, M Nazmul and Sultana, Munawar and Hossain, M Anwar

Journal: Brazilian Journal of Microbiology

Journal

Molecular epidemiology of SARS-CoV-2 in diverse environmental samples globally

Authors: Islam, Ariful and Sayeed, Md Abu and Kalam, Md Abul and Ferdous, Jinnat and Rahman, Md Kaisar and Abedin, Josefina and Islam, Shariful and Shano, Shahanaj and Saha, Otun and Shirin, Tahmina and others

Journal: Microorganisms

Journal

Parallel outbreaks of deadly pathogens (SARS-CoV-2, H5N8, EVD, black fungi) around east Africa and Asia in 2021: priorities for outbreak management with socio-economic and public health impact

Authors: Khan, Afroza and Ema, Nayeema Talukder and Rakhi, Nadira Naznin and Saha, Otun and Ahamed, Tamer and Rahaman, Md Mizanur

Journal: COVID

Journal

Evolutionary dynamics and epidemiology of endemic and emerging coronaviruses in humans, domestic animals, and wildlife

Authors: Islam, Ariful and Ferdous, Jinnat and Islam, Shariful and Sayeed, Md Abu and Dutta Choudhury, Shusmita and Saha, Otun and Hassan, Mohammad Mahmudul and Shirin, Tahmina

Journal: Viruses

Journal

First report from Bangladesh on genetic diversity of multidrug-resistant Pasteurella multocida type B: 2 in fowl cholera, Veterinary World, 14 (9): 2527-2542

Authors: Saha, O and Islam, MR and Rahman, MS and Hoque, MN and Hossain, MA and Sultana, M

Journal: Veterinary World

Journal

Transmission dynamics and susceptibility patterns of SARS-CoV-2 in domestic, farmed and wild animals: Sustainable One Health surveillance for conservation and public health to prevent future epidemics and pandemics

Authors: Islam, Ariful and Ferdous, Jinnat and Islam, Shariful and Sayeed, Md Abu and Rahman, Md Kaisar and Saha, Otun and Hassan, Mohammad Mahmudul and Shirin, Tahmina

Journal: Transboundary and Emerging Diseases

Journal

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals

Authors: Islam, Ariful and Ferdous, Jinnat and Sayeed, Md Abu and Islam, Shariful and Kaisar Rahman, Md and Abedin, Josefina and Saha, Otun and Hassan, Mohammad Mahmudul and Shirin, Tahmina

Journal: PLoS One

Journal

Genomic characterization of the dominating Beta, V2 variant carrying vaccinated (Oxford- AstraZeneca) and nonvaccinated COVID-19 patient samples in Bangladesh: A metagenomics and whole-genome approach

Authors: Rahaman, Md Mizanur and Sarkar, Md Murshed Hasan and Rahman, M Shaminur and Islam, M Rafiul and Islam, Israt and Saha, Otun and Akter, Shahina and Banu, Tanjian Akhtar and Jahan, Iffat and Habib, Md Ahasan and others

Journal: Journal of Medical Virology

Journal

Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation

Authors: Mahfuz, AMUB and Khan, Md Arif and Sajib, Emran Hossain and Deb, Anamika and Mahmud, Shafi and Hasan, Mahmudul and Saha, Otun and Islam, Ariful and Rahaman, Md Mizanur

Journal: Infection, Genetics and Evolution

Journal

Transmission pathways and genomic epidemiology of emerging variants of SARS-CoV-2 in the environment

Authors: Islam, Ariful and Sayeed, Md Abu and Kalam, Md Abul and Fedous, Jinnat and Shano, Shahanaj and Abedin, Josefina and Islam, Shariful and Choudhury, Shusmita Dutta and Saha, Otun and Hassan, Mohammad Mahmudul

Journal: Covid

Journal

Transmission dynamics and genomic epidemiology of emerging variants of SARS-CoV-2 in Bangladesh

Authors: Sayeed, Md Abu and Ferdous, Jinnat and Saha, Otun and Islam, Shariful and Choudhury, Shusmita Dutta and Abedin, Josefina and Hassan, Mohammad Mahmudul and Islam, Ariful

Journal: Tropical Medicine and Infectious Disease

Journal

Antibiogram and virulence profiling reveals multidrug resistant Staphylococcus aureus as the predominant aetiology of subclinical mastitis in riverine buffaloes

Authors: Hoque, M Nazmul and Talukder, Anup Kumar and Saha, Otun and Hasan, Mehedi Mahmudul and Sultana, Munawar and Rahman, ANM Aminoor and Das, Ziban Chandra

Journal: Veterinary Medicine and Science

Journal

Epidemiology and molecular characterization of avian influenza virus in backyard poultry of Chattogram, Bangladesh

Authors: Dutta, Pronesh and Islam, Ariful and Sayeed, Md Abu and Rahman, Md Ashiqur and Abdullah, Md Sadeque and Saha, Otun and Rahman, Mohammed Ziaur and Klaassen, Marcel and Hoque, Md Ahasanul and Hassan, Mohammad Mahmudul

Journal: Infection, Genetics and Evolution

Journal

Genomic variability correlates with biofilm phenotypes in multidrug resistant clinical isolates of Pseudomonas aeruginosa

Authors: Islam, Ovinu Kibria and Islam, Israt and Saha, Otun and Rahaman, Md Mizanur and Sultana, Munawar and Bockm{\"u

Journal: Scientific Reports

Journal

Ashaduzzaman Green synthesis of iron oxide nanoparticle using Carica papaya leaf extract: Application for photocatalytic degradation of remazol yellow RR dye and antibacterial activity

Authors: Saha, O and Rahaman, M and Sharif, JI and Habiba, O

Journal: Heliyon

Journal

Bacterial profile, antimicrobial resistance, and molecular detection of ESBL and quinolone resistance gene of uropathogens causing urinary tract infection in the southeastern part of Bangladesh

Authors: Sultana, Khandokar Fahmida and Akter, Asma and Saha, Sumita Rani and Ahmed, Firoz and Alam, Sameeha and Jafar, Tamanna and Saha, Otun

Journal: Brazilian Journal of Microbiology

Journal

Characterization of multidrug and heavy metal resistance of carbapenemases producing Klebsiella pneumoniae from poultry samples in Bangladesh

Authors: Saha, Otun and Basri, Rabeya and Hossain, Md Anwar and Sultana, Munawar

Journal: Veterinary Medicine and Science

Journal

Heliyon green synthesis of iron oxide nanoparticle using Carica papaya leaf extract: application for photocatalytic degradation of remazol yellow RR dye and antibacterial activity

Authors: Hossen, S and Yusuf, M and Chandra, S and Das, T and Saha, O and Rahaman, M and Islam, J

Journal: Heliyon

Journal

In silico functional characterization of a hypothetical protein from Pasteurella multocida reveals a novel S-Adenosylmethionine-dependent methyltransferase activity

Authors: Masum, Md Habib Ullah and Rajia, Sultana and Bristi, Uditi Paul and Akter, Mir Salma and Amin, Mohammad Ruhul and Shishir, Tushar Ahmed and Ferdous, Jannatul and Ahmed, Firoz and Rahaman, Md Mizanur and Saha, Otun

Journal: Bioinformatics and Biology Insights

Journal

Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis

Authors: Shishir, Tushar Ahmed and Saha, Otun and Rajia, Sultana and Mondol, Spencer Mark and Masum, Md Habib Ullah and Rahaman, Md Mizanur and Hossen, Foysal and Bahadur, Newaz Mohammed and Ahmed, Firoz and Naser, Iftekhar Bin and others

Journal: Scientific Reports

Journal

Thermally induced Fe2O3 spikes decorated Ag/Fe2O3 nanocomposite fabrication for anti-bacterial and anti-cancer activities

Authors: Hossain, Md Kaium and Mishra, Anshuman and Tiwari, Aanshi and Pant, Bishweshwar and Dey, Shaikat Chandra and Tiwari, Ayushi and Saha, Otun and Rahaman, Md Mizanur and Shukla, Yogesh R and Tiwari, Ashutosh and others

Journal: SN Applied Sciences

Journal

In-silico identification of novel natural drug leads against the Ebola virus VP40 protein: A promising approach for developing new antiviral therapeutics

Authors: Siddiquee, Noimul Hasan and Hossain, Md Ifteker and Talukder, Md Enamul Kabir and Nirob, Syed Afnan Arefin and Shourav, Md and Jahan, Israt and Tamanna, Umme Habiba Akter and Das, Pinky and Akter, Rahima and Hasan, Mahmudul and others

Journal: Informatics in Medicine Unlocked

Journal

Unveiling the antiviral activity of 2′, 3, 5, 7-Tetrahydroxyflavanone as potential inhibitor of chikungunya virus envelope glycoprotein

Authors: Siddiquee, Noimul Hasan and Malek, Salina and Tanni, Afsan Ara and Mitu, Israt Jahan and Arpa, Sanjida Hossain and Hasan, Md Rakibul and Shammi, Sayeda Eshmita Jahan and Chakma, Cotton and Mahinur, Mahinur and Wajed, Shah and others

Journal: Informatics in Medicine Unlocked

Journal

In silico design and evaluation of multi-epitope dengue virus vaccines: A promising approach to combat global dengue burden

Authors: Saha, Otun and Razzak, Abdur and Sarker, Nikkon and Rahman, Nymur and Zahid, Abdullah bin and Sultana, Afroza and Shishir, Tushar Ahmed and Bahadur, Newaz Mohammed and Rahaman, Md Mizanur and Hossen, Foysal and others

Journal: Discover Applied Sciences

Journal

Development of a Novel mRNA Vaccine Against Shigella Pathotypes Causing Widespread Shigellosis Endemic: An In-Silico Immunoinformatic Approach

Authors: Razzak, Abdur and Saha, Otun and Sultana, Khandokar Fahmida and Amin, Mohammad Ruhul and Zahid, Abdullah bin and Sultana, Afroza and Bristi, Uditi Paul and Rajia, Sultana and Sarker, Nikkon and Rahaman, Md Mizanur and others

Journal: Bioinformatics and Biology Insights

Journal

Interfacially self-assembled Fe2O3 nanoparticles decorated kaolinite for high performance anti-bacterial and anti-cancerous agents

Authors: Ashaduzzaman, Md and Saha, Dipti and Saha, Otun and Rahaman, Md Mizanur and Mustary, Nusrat

Journal: Inorganic and Nano-Metal Chemistry

Journal

Epidemiological pattern and genomic insights into multidrug-resistant ST491 Acinetobacter baumannii BD20 isolated from an infected wound in Bangladesh: Concerning co-occurrence of three classes of beta lactamase genes

Authors: Islam, Israt and Mubashshira, Badriya and Mondol, Spencer Mark and Saha, Otun and Rahman, M Shaminur and Khan, Afroza and Rahaman, Md Mizanur and others

Journal: Journal of Global Antimicrobial Resistance

Journal

Antiviral activity, Pharmacoinformatics, molecular docking, and dynamics studies of Azadirachta indica against Nipah virus by targeting envelope glycoprotein: emerging strategies for developing antiviral treatment

Authors: Saha, Otun and Siddiquee, Noimul Hasan and Akter, Rahima and Sarker, Nikkon and Bristi, Uditi Paul and Sultana, Khandokar Fahmida and Remon, SM Lutfor Rahman and Sultana, Afroza and Shishir, Tushar Ahmed and Rahaman, Md Mizanur and others

Journal: Bioinformatics and Biology Insights

Journal

A whole-genome metagenomic approach to explore the gut microbiome of inflammatory bowel disease patients in Bangladesh

Authors: Siam, Md Hasanul Banna and Mondol, Spencer Mark and Shakil, Md Shahriar Kabir and Islam, Md Rafiul and Islam, Israt and Saha, Otun and Amiruzzaman and Datta, Raj and Ahmed, Toufiq and Gomes, Donald James and others

Journal: Microbiology Resource Announcements

Journal

Resistome diversity in bovine clinical mastitis microbiome, a signature concurrence

Authors: Islam, Ovinu Kibria and Siddiki, Amam Zonaed and Hossain, M Anwar and Saha, Otun and Istiaq, Arif and Abir, Ruhshan Ahmed and Hoque, M Nazmul and Crandall, Keith A and Gibson, Keylie M and Sultana, Munawar and others

Journal: (No Title)

Journal

Antiviral Activity, Pharmacoinformatics, Molecular Docking, and Dynamics Studies of Against Nipah Virus by Targeting Envelope Glycoprotein: Emerging Strategies for Developing Antiviral Treatment

Journal: Bioinformatics and Biology Insights

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Masters - 2015-16

Rahima Akter

Unknown

Thesis Title: Genome-wide Analysis of Nipah virus and a Step Towards Discovering a New Medication for Nipah virus from Phytochemicals (Azadirachta indica) Utilizing an In-silico Drug Design Technology

Overview: The Nipah virus (NiV) belongs to the Henipavirus genus under the Paramyxoviridae subfamily. NiV has become a serious concern to domestic animals and people since it first appeared in Malaysia in 1998. Significant outbreaks are more concerning since person-to-person transmission is also frequent. In this study, we employed in-silico approaches to find promising therapeutic candidates to combat NiV infection. Since there aren't any approved treatments for NiV infection, we considered the enveloped attachment glycoprotein of NiV for our drug design approach. Our in-silico drug design approach included molecular docking, post-docking MM-GBSA, ADMET, and molecular dynamics (MD) simulations. We retrieved 418 phytochemicals associated with the neem plant (Azadiractha indica) from the IMPAAT database, and we used molecular docking to ascertain the compounds' binding affinities. The top three phytochemicals with binding affinities of -7.118, -7.074, and -6.894 kcal/mol for CIDs 5280343, 9064, and 5280863, respectively, were selected for additional study based on molecular docking. The post-docking MM-GBSA of those three compounds was then used to validate the molecular docking results. As evidence of their efficacy and safety, all the chosen drugs had favorable toxicological and pharmacokinetic (Pk) qualities. We also performed MD simulations to confirm the stability of the protein- ligand complex structures and determine whether the selected compounds are stable at the protein binding site. All three phytochemicals appeared to have better binding stability to the target protein than control ribavirin, according to the examination of the MD simulation results. Overall, this work offers a viable approach to developing novel medications for treating NiV infection.

Institutional Email otun.saha@nstu.edu.bd
Personal Email otun.saha@gmail.com
Mobile number 01725830666
Emergency Contact 5093365063
PABXN/A
Website N/A