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Noakhali Science and Technology University

Phone: 02334496522 Fax:02334496523 registrar@office.nstu.edu.bd

Department of Biotechnology and Genetic Engineering

Academic Profile of Shuvo Chandra Das

Shuvo Chandra Das

About Shuvo Chandra Das

I am a molecular biologist with a deep passion for teaching, research, acquiring new skills, knowledge, and an ever-enthusiastic mind to understand the molecular aspects of diverse biological phenomena. For the last five years, I have been exploring my research interests in academia. Currently, I am working as a Faculty member at the Department of Biotechnology and Genetic Engineering (BGE) in Noakhali Science and Technology University (NSTU). Before that, I worked as a Scientific Officer at Globe Biotech Limited (GBL) where I was involved in the development of stable cell lines for the production of Derbapoetin alfa in mammalian cell. Throughout my tenure at GBL, I actively engaged in various molecular techniques, including mammalian cell culture, Transfection, dot blot, ELISA, PCR, Western blotting, and others. Prior to joining GBL, I received my M.S. (2017) and B.Sc. (2015) in Genetic Engineering and Biotechnology from the University of Chittagong, Bangladesh. Besides, I have around two years of research experience (from Nov. 2015 to Nov. 2017) as a research student at Laboratory of Molecular Genetics, Department of Genetic Engineering & Biotechnology, University of Chittagong.

My research interests and efforts encompass Molecular biology, Microbial pathogenesis, Immunology, Cancer Biology, Development of novel drugs, diagnostic and treatment strategies. I am also highly enthusiastic about the Genetic basis of disease and understanding how genetic variations contribute to the onset and progression of various health conditions. I am further motivated to apply the knowledge of 'Omics' science to dissect and understand the complex biological mechanisms. To support my research vision, I have combined both experimental and computational methods, and actively collaborated with the University of Chittagong, National Institute of Biotechnology (NIB), ICDDR, Band Bangladesh Reference Institute for Chemical Measurements.

My research works have been published so far in leading peer-reviewed journals such as PLOS ONE, Genomics and Informatics, Egyptian Journal of Medical Human Genetics, Bangladesh Medical Council Bulletin etc. I have been awarded the National Science and Technology Fellowship by Bangladesh Government and Publication award by NSTU Research Cell. My projects are also funded through University Grants Commission Bangladesh, NACTER, NSTU Research Cell etc.

Publications

1. Munim, A., Das, S.C., Hossain, M.M., Hami, I., Topu, M.G. and Gupta, S.D., 2023. Unveiling multi-drug resistant (MDR) gram negative pathogenic bacteria from poultry chickens in the Noakhali region of Bangladesh. PloS one, 19(8), p.e0292638. [Q1 Ranked]

2. Das, S.C., Rahman, M.A. and Das Gupta, S., 2022. In-silico analysis unravels the structural and functional consequences of non-synonymous SNPs in the human IL-10 gene. Egyptian Journal of Medical Human Genetics, 23(1), p.10. [Q4 Ranked]

3. Islam, N.N., Das, S.C., Hossain, M., Seuti, S.A., Sultana, R. and Chowdhury, M.A., 2022. Identification and Integrative Bioinformatics Analysis of Common and Rare Mutations in the Patients with Transfusion Dependent HbE/b and β-thalassemia in Chittagong, Bangladesh. Bangladesh Medical Research Council Bulletin, 48(3), pp.180-188. [Q4 Ranked]

4. Das, S. C., Sarker, A., Saha, S. and Chakraborty, P., 2022. COVID-19 in Bangladesh: An Exploratory Data Analysis and Prediction of Neurological Syndrome Using Machine Learning Algorithms Based on Comorbidity. In Machine Intelligence and Data Science Applications: Proceedings of MIDAS 2021 (pp. 595-608). Singapore: Springer Nature Singapore.

5. Hossain, M., Das, S.C., Raza, M.T., Ahmed, I.U., Eva, I.J., Karim, T., Chakraborty, P. and Gupta, S.D., 2021. Immediate and post-COVID complications of symptomatic and asymptomatic COVID-19 patients in Bangladesh: a cross-sectional retrospective study. Asian Journal of Medical and Biological Research, 7(2), 191–201. [*Corresponding Author]

6. Chakma, V., Barman, D.N., Das, S.C., Hossain, A., Momin, M.B., Tasneem, M. and Gupta, S.D., 2023. In silico analysis of a novel hypothetical protein (YP_498675. 1) from Staphylococcus aureus unravels the protein of tryptophan synthase beta superfamily (Try-synth-beta_ II). Journal of Genetic Engineering and Biotechnology, 21(1), p.135. [Q2 Ranked]

7. Mitu, F.S., Hossain, M.M., Das, S.C., Islam, M.M., Barman, D.N. and Das Gupta, S., 2024. Association of SLC30A8 rs13266634 gene polymorphism with type 2 diabetes mellitus (T2DM) in a population of Noakhali, Bangladesh: a case–control study. Egyptian Journal of Medical Human Genetics, 25(1), p.22. [Q4 Ranked]

8. Sultana, M., Islam, M.M., Hossain, M.M., Rahman, M.A., Das, S.C., Barman, D. N., Mitu, F.S. and Gupta, S.D., 2023. Association of CAPN10 gene (rs3842570) polymorphism with the type 2 diabetes mellitus among the population of Noakhali region in Bangladesh: a case-control study. Genomics & Informatics, 21 (3): e33 [Q2 Ranked]

9. Rahman, M.A., Talukder, A., Das, S.C., Hossain, I., Devnath, P., Bhowmik, S., Uddin, M.S. and Rahman, M.M., 2020. Lactobacillus xylosus isolated from butter showed potentiality to be used as probiotic and biopreservative. Asian Journal of Medical and Biological Research, 6(1), pp.27-37.

10. Islam, N.N., Hossain, M., Das, S.C. and Alam, S., Assessment of molecular and clinical characteristics in blood transfusion dependent HbE/β-thalassemia patients. Jahangirnagar University Journal of Biological Sciences, 9(1-2), pp.109-121.

Experiences and Activities

Experience:

Professional/ Academic Appointments

1.Noakhali Science and Technology University Noakhali, Bangladesh Assistant Professor of Biotechnology and Genetic Engineering.
Feb 2021 – present
2.Noakhali Science and Technology University Noakhali, Bangladesh Lecturer of Biotechnology and Genetic Engineering
Feb 2019 - Feb 2021
3.Globe Biotech Limited Dhaka, Bangladesh Scientific Officer
Apr 2018 - Dec 2018
4. Bangamata National Cellular and Molecular Research Centre Dhaka, Bangladesh Research Associate
Nov 2017 – Mar 2018
5. University of Chittagong Chittagong, Bangladesh Research Assistant, Genetic Engineering & Biotechnology Dept.
July 2015 – Oct 2017

Professional Affiliation/ Membership

1. Member, Academic Committee, Dept. of Biotechnology and Genetic Engineering, Noakhali Science and Technology University (NSTU)

2. Member, Curriculum Development Committee, Dept. of Biotechnology and Genetic Engineering, NSTU

3.Member, Laboratory Inspection Committee, Dept. of Biotechnology and Genetic Engineering, NSTU

4.Member, Undergraduate Admission Committee, Faculty of Science, NSTU

5.Life Member, Thalassemia Welfare Center- Bangladesh

6.General Member, Bangladesh Association of Biotechnology Graduates (BABG)



Completed Funded Research

1.Title: GABRG3 (rs208129) and ATP2B2 (rs35678) gene polymorphisms and susceptibility to autism spectrum disorders in Bangladeshi children Description: The current consensus is that several genetic, epigenetic, and environmental factors contribute to the clinical and neurobiological heterogeneity of ASD. The frequency of ASD has alarmingly increased worldwide, yet there is a notable lack of study investigating the risk factors linked to ASD specifically in Bangladesh. Hence, the aim of the study is to investigate the influence of GABRG3 (rs208129) and ATP2B2 (rs35678) polymorphisms on the etiology of ASD in the Bangladeshi population. Role: Principal Investigator. Status of Support: Completed, Source of support: Research cell NSTU, Dates of Approved Project: 01/06/23-01/06/24. Primary Place of performance: NSTU, Bangladesh.


2. Title: Investigation of multi-drug resistant (MDR) pathogenic bacteria from poultry chickens, Bangladesh Description: Rapidly increasing antibiotic-resistant bacterial strains in Bangladesh’s food and farm animals stem from the excessive and inappropriate use of antibiotics. To assess the prevalence of multi drug resistant (MDR) gram-negative bacteria in poultry chicks, we seek to isolate and identify strains carrying antimicrobial resistance genes. Isolation and identification will be involved biochemical tests, 16S rRNA sequencing, and PCR screening of species-specific genes. Role: Co- PI Status of Support: Completed, Source of support: Research cell NSTU, Dates of Approved Project: 01/06/21-01/06/23, PI- Dr. Shipan Das Gupta. Primary Place of performance: NSTU, Bangladesh.


3. Title: Association of genetic polymorphism with the type 2 diabetes mellitus among the population of Noakhali region in Bangladesh Description: This study aimed at filling the gap by evaluating the plausible association of CAPN10 (rs3842570) and SLC30A8 (rs13266634) gene polymorphisms, with the development of T2DM risk among the people of the Noakhali region in Bangladesh. Additionally, we examined the association of CAPN10 and SLC30A8 with anthropometric and metabolic traits among type 2 diabetes mellitus. Role: Co- PI Status of Support: Completed, Source of support: Research cell NSTU, Dates of Approved Project: 01/06/21-01/06/22. PI- Dr. Shipan Das Gupta, Primary Place of performance: NSTU, Bangladesh.



Courses Taught at Noakhali Science and Technology University Undergraduate Courses Microbiology (with Lab) | Fundamentals of Biology (With lab) | Human Physiology (with Lab) | Molecular Biology –I | Cell and Developmental Biology | Analytical Methods (With Lab) | Microbial Genetics | Immunology | Bioinformatics | Bioprocess Technology | Postgraduate (Masters) Courses Molecular Oncology | Industrial Biotechnology | Research Projects Completed as an Employee 1.Scientific Officer: Project Involvement: a) Development of stable clones for the production of Darbepoetin alfa in mammalian cells b) Process and product validation of the targeted bio-similar drug Institution: Globe Biotech Ltd. Tejgaon Shahid Tajuddin Ahmed Avenue, Globe Office Rd, Dhaka. Duration: Apr 2018 - Dec 2018

2.Research Associate. Project Involvement: Designing Laboratory set-up and help in writing projects proposals for Bangamata National Cellular and Molecular Research Centre PI: Dr. Abu Shadat Mohammod Noman (University of Chittagong) Institution: Bangladesh Medical Research Council. Duration: Nov 2017 – Mar 2018

Research Experience as a Student

1.MS Thesis: Title: Study of the HBB gene mutation of beta thalassemia patients in Chittagong region, Bangladesh. Research Supervisor: Dr. Nazneen Naher Islam (University of Chittagong, Bangladesh). Institution: Laboratory of Molecular Genetics, Department of Genetic Engineering & Biotechnology, University of Chittagong. Duration: Nov 2016- Nov 2017


2.Undergraduate Project Title: Computational structural and functional Prediction of a hypothetical protein of Arabidopsis thaliana. Mentor: Md. Amzad Hossain (Asst. Prof., Jagannath University, Ex-Faculty, University of Chittagong). Institution: Genomics, Bioinformatics and Molecular Genetics Lab, Department of Genetic Engineering and Biotechnology, University of Chittagong, Bangladesh. Duration: Nov 2014- Apr 2015 Research Works as a Supervisor


Undergraduate (Supervisor):

1.Identification of transcription levels and prognostic significance of GGCT gene in human gastric cancers using integrative bioinformatics analysis. (Ongoing research), Start date: Mar 2024.

2.Prediction of thalassemia carriers and iron deficiency anemia using machine learning algorithms in Bangladeshi patients. (Ongoing research), Start date: Mar 2024.

3.Association of HBB gene polymorphism (rs10768683) with beta thalassemia patients in Bangladesh. Duration: May 23- Nov 2023.

4.In-silico analysis and prediction of the most deleterious missense single nucleotide polymorphisms in human OXTR gene. (The study manuscript has been submitted for publication), Duration: July 22- Dec 2022.

5.Immediate and post-COVID complications of symptomatic and asymptomatic COVID-19 patients in Bangladesh: a cross-sectional retrospective study. (The study manuscript is published), Duration: Nov 2020- June 2021.


Post-graduate (Masters) Supervisor/ Co-supervisor:

1.Green synthesis of Ag-NPs from leaf extracts of Persicaria orientalis and its antimicrobial activity against multi drug resistant bacteria. (Ongoing research, supervisor), Start date: June 2024.

2.Investigation of gut microbiome in autistic and neurotypical children in Bangladesh. (It is an ongoing research, supervisor), Start date: June 2024.

3.Unraveling the genetic and environmental clues to autism spectrum disorders in Bangladesh. (Ongoing research, Supervisor), Start date: June 2023.

4.Studies towards development of novel "Antibiotic Resistance Breakers" to combat multidrug resistant ESKAPE pathogens. (Ongoing research, co- supervisor), Start date: June 2023.

5. Unveiling multi-drug resistant (MDR) gram negative pathogenic bacteria from poultry chickens in the Noakhali region of Bangladesh, Bangladesh. (Co-supervisor, accepted by PLOS ONE journal, Duration: June 2021- Nov 2022.

6. Association of CAPN10 gene (rs3842570) polymorphisms with Type 2 Diabetes Mellitus (T2DM) among the population of Noakhali region in Bangladesh: a case control study. (Co-supervisor, published in genomics and informatics journal), Duration: July 2021- Nov 2022. Technical Experiences Wet Lab: Mammalian Cell Culture | Transfection of Mammalian Cell | Development of stable clone | Gene Cloning | Culture of Microorganisms | Bacterial Plasmid and Genomic DNA extraction | DNA Extraction from Blood | Protein Extraction | PCR | Agarose Gel Electrophoresis | SDS-PAGE | Western Blotting | Dot Blotting | Antibiotic Sensitivity Tests | Restriction Digestion of Target DNA | DNA Sequencing | Spectrophotometry | Liquid Chromatography | Dry Lab: Protein Homology Modeling | Molecular Docking | siRNA Design | Primer Design for Mutation Detection| | Functional Enrichment and Network (pathway) Analysis | Drug-Gene Interaction | Protein- protein Interaction |

Academic Awards and Achievements

1. National Science and Technology (NST) Fellowship (R &D) (2022-23) for M.S. Thesis Supervision.

Publication Award 2021-22 by NSTU Research Cell for Publishing Articles as a First author.

National Science and Technology (NST) Fellowship (2016-17) for M.S. Thesis work.

Awarded as a Best Debater in the Interdepartment Debate Competition.

Chancellor Gold Medal Award-2014, from University of Chittagong.

Chittagong University Merit Scholarship (2015) for B.Sc. (Honors) Result.

Dinajpur Board Scholarship, 2008 (S.S.C.).